Chromatography Resin Market: Top 5 Industry Applications

According to Inkwood Research, the global chromatography resin market is anticipated to progress with a CAGR of 7.64% during the forecast period of 2024 to 2032. Chromatography resins are emerging as indispensable tools in analytical chemistry and biotechnology, predominantly owing to their remarkable selectivity and versatility. 

The significant rise in research and development (R&D), specifically within the pharmaceutical & biopharmaceutical industries serves as a primary catalyst for the global chromatography resin market’s growth. 

These resins, essential for the refinement as well as the isolation of biotherapeutics, are increasingly essential across applications. These include drug discovery, biopharmaceutical production, and the enhancement of chromatography technologies, among others.

Accordingly, in this blog, we will explore the top five applications of chromatography resins, highlighting their significance across various industries.

Chromatography Resin Market - Inkwood Research

1. Protein Purification in Biopharmaceutical Industry – 

The biopharmaceutical industry relies heavily on chromatography resins for the purification of therapeutic proteins and antibodies. These resins, particularly ion exchange and affinity resins, are designed to selectively bind and separate target proteins from complex biological mixtures, such as cell culture supernatants or fermentation broths. 

Accordingly, let’s take a closer look at major companies engaged in the process of protein purification in the biopharma sector – 

  • F. Hoffmann-La Roche is a top patent filer in protein affinity chromatography and is active in diagnostic test development, biotechnology, and drug discovery. It employs protein affinity chromatography in its R&D, particularly for purifying and characterizing proteins used in diagnostics and therapeutics. 
  • E. Merck and Sanofi are also notable patent filers in this field.

In the last four years alone, there have been more than 787,000 patents filed and granted in the pharmaceutical industry, according to a 2023 report on Innovation in Pharma: Protein Affinity Chromatography.

By exploiting the unique physicochemical properties of the target molecules, chromatography resins enable the highly efficient purification of biopharmaceuticals, ensuring product safety, purity, and potency.

2. Food and Beverage Analysis:

The food and beverage industry relies on chromatography resins for the analysis and quality control of various products. Ion-exchange and size-exclusion resins are utilized for the separation and quantification of sugars, organic acids, and other food components, ensuring product quality and adherence to regulatory standards. Furthermore, affinity resins are employed for the selective removal of undesirable compounds, such as mycotoxins or allergens, from food and beverage products.

Market Position: According to Inkwood Research, food & beverage is set to be a key end use in the chromatography resin market, during the forecast years, 2024 to 2032.

With a growing demand for natural and clean-label products, chromatography resins are invaluable in isolating and purifying bioactive compounds, thereby facilitating the production of top-tier, compliant food and beverage offerings.

3. Biomolecule Separations in Academic and Research Settings –

Chromatography resins are indispensable tools in academic and research laboratories, enabling the separation and purification of a wide range of biomolecules, including proteins, nucleic acids, and carbohydrates. 

These resins are employed in various applications, such as protein structure determination, enzyme purification, and the isolation of biologically active compounds from natural sources. The versatility and selectivity of chromatography resins have facilitated numerous scientific discoveries and advancements in fields like biochemistry, molecular biology, and biotechnology.

Accordingly, Bio-Rad Laboratories Inc introduced EconoFit Low-Pressure Prepacked Chromatography Column Packs in June 2022. These packs are designed to facilitate resin screening experiments during the creation of protein purification workflows.

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4. Environmental Analysis and Remediation – 

Various World Health Organization (WHO) studies have revealed that over 10% of women face infertility risks due to exposure to prevalent environmental contaminants –  Lead, cadmium, mercury, and other heavy metals are known to cause reproductive disorders. 

Besides, numerous contaminants, such as heavy metals as well as polycyclic aromatic hydrocarbons (PAHs), have been linked to hormone imbalances.

Chromatography resins, in this regard, have emerged as valuable tools in environmental analysis and remediation processes. Ion-exchange resins, for instance, are employed for the selective removal of heavy metals and other contaminants from wastewater and industrial effluents. 

Additionally, specialized resins are utilized for the extraction and concentration of trace organic pollutants from environmental samples, facilitating their subsequent analysis and quantification.

5. Small Molecule Purification in Pharmaceutical Industry – 

Beyond biomolecules, chromatography resins play a crucial role in the purification of small organic molecules, including active pharmaceutical ingredients (APIs) and drug intermediates. Reverse-phase resins, utilizing hydrophobic interactions, are widely employed for the separation and purification of these compounds. This application is particularly important in the pharmaceutical industry, where high purity and consistent quality of drugs are paramount for ensuring patient safety and efficacy.

As the demand for high-purity products and the need for advanced analytical techniques continue to grow, chromatography resins are projected to remain at the forefront of scientific and industrial endeavors. Ongoing research and development efforts are focused on designing novel resins with enhanced selectivity, improved capacity, and greater chemical and physical stability, further expanding the growth potential of the chromatography resin market during the forecast years.


By Shruti

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    Common types of chromatography resins include agarose for gel filtration, ion exchange resins, affinity resins, and hydrophobic interaction resins.

    The selection of chromatography resins depends on factors like the target molecule, sample characteristics, desired purity, and the specific interactions needed for separation.